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Rabbit Anti-PGAM1 Recombinant Antibody (D3J9T) (CBMAB-CP1943-LY)

The product is antibody recognizes PGAM1. The antibody D3J9T immunoassay techniques such as: WB.
See all PGAM1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Hamster, Monkey
Clone
D3J9T
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PGAM1 protein.
Specificity
Human, Mouse, Rat, Hamster, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Phosphoglycerate Mutase 1
Introduction
The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Entrez Gene ID
Human5223
Mouse18648
Rat24642
Monkey706211
Hamster100766080
UniProt ID
HumanP18669
MouseQ9DBJ1
RatP25113
MonkeyF7GGM3
HamsterA0A3Q0CEZ5
Alternative Names
Phosphoglycerate Mutase 1; Phosphoglycerate Mutase A; Nonmuscle Form; Phosphoglycerate Mutase 1 (Brain); Phosphoglycerate Mutase Isozyme B; BPG-Dependent PGAM 1; PGAM-B; PGAMA;
Function
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202).
Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202).
Biological Process
Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of pentose-phosphate shuntManual Assertion Based On ExperimentIDA:UniProtKB
Respiratory burstManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
cytoplasm
cytosol
extracellular exosome
extracellular region
ficolin-1-rich granule lumen
membrane
secretory granule lumen
PTM
Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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