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Mouse Anti-PTPRA Recombinant Antibody (21/RPTPA) (CBMAB-R0662-CN)

This product is a Mouse antibody that recognizes PTPRA. The antibody 21/RPTPA can be used for immunoassay techniques such as: WB, IF.
See all PTPRA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
21/RPTPA
Antibody Isotype
IgM
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgM
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.25 mg/mL

Target

Full Name
protein tyrosine phosphatase, receptor type, A
Introduction
This protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5786
UniProt ID
P18433
Alternative Names
LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha
Function
Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity).
Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).
Biological Process
Insulin receptor signaling pathwayIEA:Ensembl
Integrin-mediated signaling pathwayISS:UniProtKB
Modulation of chemical synaptic transmissionIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationIEA:Ensembl
Regulation of focal adhesion assemblyISS:UniProtKB
Cellular Location
Cell membrane
Cell junction, focal adhesion
Localizes to focal adhesion sites following integrin engagement.
Topology
Extracellular: 20-151
Helical: 152-174
Cytoplasmic: 175-802
PTM
Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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