Human Recombinant PTPRA protein, GST Tag (V2LY-0526-LY6400)

Name: Human Recombinant PTPRA protein, GST Tag
SKU: V2LY-0526-LY6400
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant PTPRA protein, GST Tag consist of Amino Acid: 174-793 and predicts a molecular mass of 99 kDa.

Molecule Mass

99 kDa

Sequence

Amino Acid: 174-793

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

protein tyrosine phosphatase, receptor type, A

Function

Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity).
Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).

Biological Process

Insulin receptor signaling pathwayIEA:Ensembl
Integrin-mediated signaling pathwayISS:UniProtKB
Modulation of chemical synaptic transmissionIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationIEA:Ensembl
Regulation of focal adhesion assemblyISS:UniProtKB

Cellular Location

Cell membrane
Cell junction, focal adhesion
Localizes to focal adhesion sites following integrin engagement.

Topology

Extracellular: 20-151
Helical: 152-174
Cytoplasmic: 175-802

PTM

Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant PTPRA, Active protein, GST Tag (CAT#: V2LY-0526-LY6401)

Related Products

Mouse Anti-PTPRA Recombinant Antibody (21/RPTPA) (CAT#: CBMAB-R0662-CN)

Mouse Anti-PTPRA Recombinant Antibody (5G3) (CAT#: CBMAB-P3451-YC)

Human Recombinant PTPRA, Active protein, GST Tag (CAT#: V2LY-0526-LY6401)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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