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Mouse Anti-PTPRA Recombinant Antibody (5G3) (CBMAB-P3451-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase, receptor type A. The antibody can be used for immunoassay techniques, such as WB.
See all PTPRA antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
5G3
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein tyrosine phosphatase, receptor type, A
Introduction
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation.
Entrez Gene ID
Human5786
Mouse19262
UniProt ID
HumanP18433
MouseP18052
Alternative Names
RPTPA; PTPA; HPTPalpha; PTPRL2; LRP; HLPR; PP2A; R-PTP-alpha; PPP2R4; HEPTP; HPTPA; PR53
Function
Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity).
Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity).
Biological Process
Insulin receptor signaling pathwayIEA:Ensembl
Integrin-mediated signaling pathwayISS:UniProtKB
Modulation of chemical synaptic transmissionIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationIEA:Ensembl
Regulation of focal adhesion assemblyISS:UniProtKB
Cellular Location
Cell membrane
Cell junction, focal adhesion
Localizes to focal adhesion sites following integrin engagement.
Topology
Extracellular: 20-151
Helical: 152-174
Cytoplasmic: 175-802
PTM
Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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