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Mouse Anti-SERPINA12 (AA 21-414) Recombinant Antibody (CBXS-0224) (CBMAB-S3205-CQ)

This product is a mouse antibody that recognizes SERPINA12. The antibody CBXS-0224 can be used for immunoassay techniques such as: ELISA, WB.
See all SERPINA12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0224
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.1% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 21-414

Target

Full Name
Serpin Family A Member 12
Introduction
SERPINA12 (Serpin Family A Member 12) is a Protein Coding gene. Diseases associated with SERPINA12 include Body Mass Index Quantitative Trait Locus 11 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA1.
Entrez Gene ID
145264
UniProt ID
Q8IW75
Alternative Names
Serpin Family A Member 12; Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12; Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 12; Visceral Adipose Tissue-Derived Serine Protease Inhibitor; Vaspin; OL-64; Visceral Adipose-Specific SERPIN; Visceral Adipose-Specific Serpin; Serpin A12;
Function
Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.
Biological Process
Biological Process gluconeogenesisIEA:Ensembl
Biological Process lipid biosynthetic processIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of gluconeogenesisIEA:Ensembl
Biological Process negative regulation of lipid biosynthetic processIEA:Ensembl
Biological Process phosphatidylinositol 3-kinase signalingIEA:Ensembl
Biological Process positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Biological Process regulation of cholesterol metabolic processIEA:Ensembl
Biological Process regulation of triglyceride metabolic processIEA:Ensembl
Cellular Location
Secreted
PTM
Glycosylation slightly decreases affinity for heparin, but otherwise has no significant effect on KLK7 inhibitory activity or thermal stability of the protein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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