SERPINA12

SERPINA12 (Serpin Family A Member 12) is a Protein Coding gene. Diseases associated with SERPINA12 include Body Mass Index Quantitative Trait Locus 11 and Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINA1.
Full Name
Serpin Family A Member 12
Function
Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues.
Biological Process
Biological Process gluconeogenesisIEA:Ensembl
Biological Process lipid biosynthetic processIEA:Ensembl
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of gluconeogenesisIEA:Ensembl
Biological Process negative regulation of lipid biosynthetic processIEA:Ensembl
Biological Process phosphatidylinositol 3-kinase signalingIEA:Ensembl
Biological Process positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingIEA:Ensembl
Biological Process regulation of cholesterol metabolic processIEA:Ensembl
Biological Process regulation of triglyceride metabolic processIEA:Ensembl
Cellular Location
Secreted
PTM
Glycosylation slightly decreases affinity for heparin, but otherwise has no significant effect on KLK7 inhibitory activity or thermal stability of the protein.
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Anti-SERPINA12 antibodies

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Mouse Anti-SERPINA12 Recombinant Antibody (3B3) (CBMAB-A7989-LY)

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Target: SERPINA12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B3
Application*: WB, E
Datasheet SDS

Mouse Anti-SERPINA12 Recombinant Antibody (VP63) (CBMAB-S6673-CQ)

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Target: SERPINA12
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: VP63
Application*: E, P, WB
Datasheet SDS

Mouse Anti-SERPINA12 Recombinant Antibody (CBXS-3021) (CBMAB-S5767-CQ)

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Target: SERPINA12
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3021
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-SERPINA12 Recombinant Antibody (CBXS-1836) (CBMAB-S4641-CQ)

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Target: SERPINA12
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1836
Application*: WB, IP
Datasheet SDS

Mouse Anti-SERPINA12 Recombinant Antibody (CBXS-0225) (CBMAB-S3206-CQ)

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Target: SERPINA12
Host: Mouse
Specificity: Human
Clone: CBXS-0225
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SERPINA12 (AA 21-414) Recombinant Antibody (CBXS-0224) (CBMAB-S3205-CQ)

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Target: SERPINA12
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0224
Application*: E, WB
Datasheet SDS

Mouse Anti-SERPINA12 Recombinant Antibody (CBXS-3925) (CBMAB-S0164-CQ)

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Target: SERPINA12
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXS-3925
Application*: WB, E
Datasheet SDS

Human SERPINA12 ELISA Kit (V2LY-0626-LY1266)

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Target: SERPINA12
Sensitivity: 0.01 ng/mL
Detection Range: 0.05-10 ng/mL
Sample Type: Serum, Plasma, Urine, Ascites, Cerebrospinal fluid, Tissue
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant SERPINA12 protein, His Tag (V2LY-0526-LY6717)

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Target: SERPINA12
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-414
Tag: His Tag
Datasheet SDS

SERPINA12 Matched Antibody Pair (1056) (APMAB-1056LY)

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Target: SERPINA12
Specificity: Human
Datasheet SDS

Mouse Anti-SERPINA12 Recombinant Antibody (CBXS-0226) (CBMAB-S3207-CQ)

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Target: SERPINA12
Host: Mouse
Specificity: Rat
Clone: CBXS-0226
Application*: WB, IC, P, C, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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