Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-SH3KBP1 Recombinant Antibody (CBXC-1355) (CBMAB-C5588-CQ)


See all SH3KBP1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1355
Antibody Isotype
IgG1
Application
ICC

Basic Information

Immunogen
E. coli-derived recombinant human CIN85/SH3KBP1, Pro366-Lys665, Accession # Q96B97
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH3 Domain Containing Kinase Binding Protein 1
Introduction
This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms.
Entrez Gene ID
30011
UniProt ID
Q96B97
Alternative Names
SH3 Domain Containing Kinase Binding Protein 1; Human Src Family Kinase-Binding Protein 1; Cbl-Interacting Protein Of 85 KDa; CD2-Binding Protein 3; CD2BP3; CIN85; HSB-1; SH3 Domain-Containing Kinase-Binding Protein 1; Src-Related Kinase Binding Protein-1;
Function
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
Biological Process
Biological Process positive regulation of epidermal growth factor receptor signaling pathwayISS:UniProtKB
Biological Process protein homooligomerizationIEA:InterPro
Cellular Location
Lysosome
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SH3KBP1 Recombinant Antibody (CBXC-1355)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry