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SH3KBP1

This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Full Name
SH3 Domain Containing Kinase Binding Protein 1
Function
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
Biological Process
Biological Process positive regulation of epidermal growth factor receptor signaling pathwayISS:UniProtKB
Biological Process protein homooligomerizationIEA:InterPro
Cellular Location
Lysosome
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Anti-SH3KBP1 antibodies

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Rabbit Anti-SH3KBP1 Recombinant Antibody (D1A4) (CBMAB-CP0314-LY)

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Target: SH3KBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey, Rat, Hamster, Cattle, Dog, Pig
Clone: D1A4
Application*: WB, IP
Datasheet SDS

Mouse Anti-SH3KBP1 Recombinant Antibody (1F11) (CBMAB-A8100-LY)

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Target: SH3KBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F11
Application*: WB, E
Datasheet SDS

Mouse Anti-SH3KBP1 Recombinant Antibody (CBXS-3312) (CBMAB-S6051-CQ)

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Target: SH3KBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-3312
Application*: IC, IP, WB
Datasheet SDS

Mouse Anti-SH3KBP1 Recombinant Antibody (CBXS-3311) (CBMAB-S6050-CQ)

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Target: SH3KBP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXS-3311
Application*: IP, WB
Datasheet SDS

Rabbit Anti-SH3KBP1 Recombinant Antibody (CBXS-1586) (CBMAB-S4435-CQ)

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Target: SH3KBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1586
Application*: WB, P, IF
Datasheet SDS

Rabbit Anti-SH3KBP1 Recombinant Antibody (CBXS-1585) (CBMAB-S4434-CQ)

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Target: SH3KBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1585
Application*: WB
Datasheet SDS

Mouse Anti-SH3KBP1 Recombinant Antibody (CBXS-0348) (CBMAB-S3319-CQ)

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Target: SH3KBP1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Rat
Clone: CBXS-0348
Application*: IP, WB
Datasheet SDS

Mouse Anti-SH3KBP1 Recombinant Antibody (CBXS-0347) (CBMAB-S3318-CQ)

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Target: SH3KBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBXS-0347
Application*: IC, IP, WB
Datasheet SDS

Mouse Anti-SH3KBP1 Recombinant Antibody (CBXC-1355) (CBMAB-C5588-CQ)

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Target: SH3KBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1355
Application*: IC
Datasheet SDS

Mouse Anti-SH3KBP1 Recombinant Antibody (CBYY-C0726) (CBMAB-C2149-YY)

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Target: SH3KBP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C0726
Application*: WB
Datasheet SDS

Rabbit Anti-SH3KBP1 Recombinant Antibody (CBWJC-4436) (CBMAB-C5825WJ)

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Target: SH3KBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey, Rat, Hamster, Cattle, Dog, Pig
Clone: CBWJC-4436
Application*: WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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