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Mouse Anti-SH3KBP1 Recombinant Antibody (CBXS-0347) (CBMAB-S3318-CQ)

This product is a mouse antibody that recognizes SH3KBP1. The antibody CBXS-0347 can be used for immunoassay techniques such as: ICC, IP, WB.
See all SH3KBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBXS-0347
Antibody Isotype
IgG1, κ
Application
ICC, IP, WB

Basic Information

Specificity
Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 30% glycerol
Preservative
0.05% sodium azide
Concentration
0.9 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH3 Domain Containing Kinase Binding Protein 1
Introduction
This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms.
Entrez Gene ID
84357
UniProt ID
Q925Q9
Alternative Names
CIN85; Seta
Function
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
Biological Process
Biological Process positive regulation of epidermal growth factor receptor signaling pathwayISS:UniProtKB
Biological Process protein homooligomerizationIEA:InterPro
Cellular Location
Lysosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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