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Mouse Anti-TNFRSF12A Recombinant Antibody (ITEM-4) (CBMAB-T3086-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNFRSF12A (TNF Receptor Superfamily Member 12A). The antibody can be used for immunoassay techniques, such as WB, FC, IHC, IHC-Fr.
See all TNFRSF12A antibodies
Published Data
Fig.1 Colocalization studies showing the expression of TWEAK in sections from human carotid atherosclerotic plaques.
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Fig.2 Western blot showing TWEAK expression in macrophages in the presence of sTWEAK and incubated with or without DXM and anti-CD163.
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Fig.1 Double immunofluorescence for Fn14 and LGR5 in WT mice liver 48 hours after PH (magnification 20×).
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Fig.2 Fn14 normalized to Immunohistochemistry (magnification 20×).
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Fig.3 Representative western blot, quantification of protein levels for Fn14 normalized to β-actin.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
ITEM-4
Antibody Isotype
IgG2b, κ
Application
WB, FC, IHC, IHC-Fr

Basic Information

Immunogen
The immunogen for this antibody is TWEAKR
Specificity
Human, Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tumor necrosis factor receptor superfamily, member 12A
Introduction
TNF Receptor Superfamily Member 12A is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Akt Signaling.
Entrez Gene ID
Human51330
Mouse27279
UniProt ID
HumanQ9NP84
MouseQ9CR75
Alternative Names
TNF Receptor Superfamily Member 12A; Fibroblast Growth Factor-Inducible Immediate-Early Response Protein 14; FGF-Inducible 14; Tweak-Receptor; TWEAKR; FN14
Function
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process cell adhesion Source:UniProtKB-KW
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process regulation of wound healing Source:UniProtKB1 Publication
Cellular Location
Membrane
Topology
Extracellular: 28-80
Helical: 81-101
Cytoplasmic: 102-129
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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