HSD3B1 Matched Antibody Pair (574) (APMAB-574LY)

Name: HSD3B1 Matched Antibody Pair (574)
SKU: APMAB-574LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-HSD3B1 polyclonal antibody, 100 ug

Detection Antibody

Anti-HSD3B1 Mouse monoclonal, IgG1 antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016]

Alternative Names

Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1; 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type I; Short Chain Dehydrogenase/Reductase Family 11E, Member 1; Trophoblast Antigen FDO161G; 3-Beta-HSD I; HSDB3A; 3 Beta-Hydroxysteroid Dehydrogenase/Delta 5-->4-Isomerase Type 1; 3-Beta-Hydroxy-Delta(5)-Steroid Dehydrogenase; 3-Beta-Hydroxy-5-Ene Steroid Dehydrogenase; Delta-5-3-Ketosteroid Isomerase;

Entrez Gene ID

3283

UniProt ID

P14060

More Infomation

Cui, D., Li, J., Zhu, Z., Berk, M., Hardaway, A., McManus, J., ... & Sharifi, N. (2023). Cancer-associated fibroblast-secreted glucosamine alters the androgen biosynthesis program in prostate cancer via HSD3B1 upregulation. The Journal of Clinical Investigation, 133(7).

Kruse, M. L., Patel, M., McManus, J., Chung, Y. M., Li, X., Wei, W., ... & Sharifi, N. (2021). Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer. JCI insight, 6(20).

Zein, J., Gaston, B., Bazeley, P., DeBoer, M. D., Igo Jr, R. P., Bleecker, E. R., ... & Sharifi, N. (2020). HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma. Proceedings of the National Academy of Sciences, 117(4), 2187-2193.

Thomas, L., & Sharifi, N. (2020). Germline HSD3B1 genetics and prostate cancer outcomes. Urology, 145, 13-21.

Hearn, J. W., Sweeney, C. J., Almassi, N., Reichard, C. A., Reddy, C. A., Li, H., ... & Sharifi, N. (2020). HSD3B1 genotype and clinical outcomes in metastatic castration-sensitive prostate cancer. JAMA oncology, 6(4), e196496-e196496.

Sabharwal, N., & Sharifi, N. (2019). HSD3B1 genotypes conferring adrenal-restrictive and adrenal-permissive phenotypes in prostate cancer and beyond. Endocrinology, 160(9), 2180-2188.

Alyamani, M., Emamekhoo, H., Park, S., Taylor, J., Almassi, N., Upadhyay, S., ... & Sharifi, N. (2018). HSD3B1 (1245A> C) variant regulates dueling abiraterone metabolite effects in prostate cancer. The Journal of Clinical Investigation, 128(8), 3333-3340.

Hettel, D., & Sharifi, N. (2018). HSD3B1 status as a biomarker of androgen deprivation resistance and implications for prostate cancer. Nature Reviews Urology, 15(3), 191-196.

Almassi, N., Reichard, C., Li, J., Russell, C., Perry, J., Ryan, C. J., ... & Sharifi, N. (2018). HSD3B1 and response to a nonsteroidal CYP17A1 inhibitor in castration-resistant prostate cancer. JAMA oncology, 4(4), 554-557.

Hearn, J. W., Xie, W., Nakabayashi, M., Almassi, N., Reichard, C. A., Pomerantz, M., ... & Sharifi, N. (2018). Association of HSD3B1 genotype with response to androgen-deprivation therapy for biochemical recurrence after radiotherapy for localized prostate cancer. JAMA oncology, 4(4), 558-562.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Hsd3b1 ELISA Kit (CAT#: V2LY-0626-LY1651)

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Rat Hsd3b1 ELISA Kit (CAT#: V2LY-0626-LY1651)

Mouse Anti-HSD3B1 Recombinant Antibody (FDO66Q) (CAT#: CBMAB-H3033-FY)

Mouse Anti-HSD3B1 (AA 1-374) Monoclonal Antibody (CBFYH-3208) (CAT#: CBMAB-H3032-FY)

Mouse Anti-HSD3B1 Recombinant Antibody (3C11-D4) (CAT#: CBMAB-A4103-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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