HSD3B1

The protein encoded by this gene is an enzyme that catalyzes the oxidative conversion of delta-5-3-beta-hydroxysteroid precursors into delta-4-ketosteroids, which leads to the production of all classes of steroid hormones. The encoded protein also catalyzes the interconversion of 3-beta-hydroxy- and 3-keto-5-alpha-androstane steroids. [provided by RefSeq, Jun 2016]
Full Name
Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1
Function
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta5-steroid precursors to 3-oxo-Delta4-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411).

Expected to use NAD+ as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable).
Biological Process
Androgen biosynthetic process Source: UniProtKB
C21-steroid hormone metabolic process Source: GO_Central
Estrogen biosynthetic process Source: UniProtKB
Hippocampus development Source: GO_Central
Response to corticosterone Source: GO_Central
Steroid biosynthetic process Source: UniProtKB
Cellular Location
Mitochondrion membrane; Endoplasmic reticulum membrane
Topology
Helical: 288-308
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Anti-HSD3B1 antibodies

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Mouse Anti-HSD3B1 Recombinant Antibody (3C11-D4) (CBMAB-A4103-LY)

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Target: HSD3B1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C11-D4
Application*: WB, E
Datasheet SDS

Mouse Anti-HSD3B1 Recombinant Antibody (CBFYH-2023) (CBMAB-H3036-FY)

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Target: HSD3B1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2023
Application*: WB, P, C, F
Datasheet SDS

Mouse Anti-HSD3B1 Recombinant Antibody (FDO66Q) (CBMAB-H3033-FY)

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Target: HSD3B1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle
Clone: FDO66Q
Application*: P, C, IC, IF
Datasheet SDS

Mouse Anti-HSD3B1 (AA 1-374) Monoclonal Antibody (CBFYH-3208) (CBMAB-H3032-FY)

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Target: HSD3B1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-3208
Application*: WB, IH
Datasheet SDS

Rat Hsd3b1 ELISA Kit (V2LY-0626-LY1651)

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Target: Hsd3b1
Sensitivity: 0.021 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Rabbit Anti-HSD3B1 Recombinant Antibody (
10G2) (V2LY-0725-LY930)

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Target: HSD3B1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10G2
Application*: E, IH, IF, F
Datasheet SDS

HSD3B1 Matched Antibody Pair (574) (APMAB-574LY)

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Target: HSD3B1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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