Human CALD1 ELISA Kit (V2LY-0626-LY1686)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.0043 ng/mL
Detection Range
0.008-1.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
93.2 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Caldesmon 1
Function
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Biological Process
Actin filament bundle assembly Source: GO_Central
Angiogenesis Source: GO_Central
Muscle contraction Source: Reactome
Cellular Location
Cytoskeleton; Stress fiber; Myofibril. On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).
PTM
In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).

Papke, D. J., Oliveira, A. M., Chou, M. M., & Fletcher, C. D. (2021). Morphologically malignant nodular fasciitis with CALD1-USP6 fusion. Virchows Archiv, 1-6.

Mamoor, S. (2021). CALD1 is differentially expressed in lymph node metastasis in human breast cancer.

Zheng, H., Bai, Y., Wang, J., Chen, S., Zhang, J., Zhu, J., ... & Wang, X. (2021). Weighted Gene Co-expression Network Analysis Identifies CALD1 as a Biomarker Related to M2 Macrophages Infiltration in Stage III and IV Mismatch Repair-Proficient Colorectal Carcinoma. Frontiers in molecular biosciences, 8.

Cheng, Q., Tang, A., Wang, Z., Fang, N., Zhang, Z., Zhang, L., ... & Zeng, Y. (2021). CALD1 Modulates Gliomas Progression via Facilitating Tumor Angiogenesis. Cancers, 13(11), 2705.

Śnit, M., Nabrdalik, K., Długaszek, M., Gumprecht, J., Trautsolt, W., Górczyńska-Kosiorz, S., & Grzeszczak, W. (2017). Association of rs 3807337 polymorphism of CALD1 gene with diabetic nephropathy occurrence in type 1 diabetes—preliminary results of a family-based study. Endokrynologia Polska, 68(1), 13-17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

CALD1 Matched Antibody Pair (169) (CAT#: APMAB-169LY)

Antibody Pairs

CALD1 Matched Antibody Pair (169) (CAT#: APMAB-169LY)

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CALD1 Matched Antibody Pair (169) (CAT#: APMAB-169LY)

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Isotype control

For research use only. Not intended for any clinical use.

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