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PA2G4 Matched Antibody Pair (839) (APMAB-839LY)

This antibody pair set can be used for detecting and quantifying protein level of human PA2G4.
See all PA2G4 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-PA2G4 polyclonal antibody, 100 ug
Detection Antibody
Anti-PA2G4 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
Alternative Names
Proliferation-Associated 2G4; Proliferation-Associated 2G4, 38kDa; Proliferation-Associated 2G4, 38kD; Cell Cycle Protein P38-2G4 Homolog; ErbB3-Binding Protein 1; HG4-1;
Entrez Gene ID
5036
UniProt ID
Q9UQ80

Hwang, I., Kim, B. S., Lee, H. Y., Cho, S. W., Lee, S. E., & Ahn, J. Y. (2024). PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia. Autophagy, 20(2), 365-379.

Massudi, H., Luo, J. S., Holien, J. K., Gadde, S., Krishan, S., Herath, M., ... & Marshall, G. M. (2023). Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface. Cancers, 15(6), 1822.

Sun, S., Liu, Y., Zhou, M., Wen, J., Xue, L., Han, S., ... & Zhang, B. (2022). PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner. Cell & Bioscience, 12(1), 55.

Hou, X., & Tang, W. (2021). Pseudogene PA2G4P4 promotes oncogene PA2G4 expression and nuclear translocation to affect glioblastoma cell viability and apoptosis. Life Sciences, 265, 118793.

Xu, Y., Cai, H., Tu, W., Ding, L., & Luo, R. (2021). Increased PA2G4 expression is an unfavorable factor in nasopharyngeal carcinoma. Applied Immunohistochemistry & Molecular Morphology, 29(7), 513-518.

Stevenson, B. W., Gorman, M. A., Koach, J., Cheung, B. B., Marshall, G. M., Parker, M. W., & Holien, J. K. (2020). A structural view of PA2G4 isoforms with opposing functions in cancer. Journal of Biological Chemistry, 295(47), 16100-16112.

Koach, J., Holien, J. K., Massudi, H., Carter, D. R., Ciampa, O. C., Herath, M., ... & Marshall, G. M. (2019). Drugging MYCN oncogenic signaling through the MYCN-PA2G4 binding interface. Cancer research, 79(21), 5652-5667.

Huang, X., He, M., Huang, S., Lin, R., Zhan, M., Yang, D., ... & Wang, J. (2019). Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription. Molecular Cancer, 18, 1-19.

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For research use only. Not intended for any clinical use.

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