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EGF

This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Full Name
Epidermal Growth Factor
Research Area
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).
Biological Process
Angiogenesis Source: HGNC-UCL
Branching morphogenesis of an epithelial tube Source: Ensembl
Epidermal growth factor receptor signaling pathway Source: BHF-UCL
Epidermal growth factor receptor signaling pathway via MAPK cascade Source: UniProtKB
ERK1 and ERK2 cascade Source: UniProtKB
Mammary gland alveolus development Source: Ensembl
Negative regulation of cholesterol efflux Source: Ensembl
Negative regulation of secretion Source: BHF-UCL
Peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cell population proliferation Source: HGNC-UCL
Positive regulation of cerebellar granule cell precursor proliferation Source: Ensembl
Positive regulation of DNA binding Source: UniProtKB
Positive regulation of DNA replication Source: UniProtKB
Positive regulation of endothelial cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
Positive regulation of epithelial tube formation Source: BHF-UCL
Positive regulation of gene expression Source: UniProtKB
Positive regulation of hyaluronan biosynthetic process Source: UniProtKB
Positive regulation of MAPK cascade Source: BHF-UCL
Positive regulation of MAP kinase activity Source: HGNC-UCL
Positive regulation of mitotic nuclear division Source: HGNC-UCL
Positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of phosphorylation Source: HGNC-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of protein localization to early endosome Source: UniProtKB
Positive regulation of receptor internalization Source: ParkinsonsUK-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of ubiquitin-dependent protein catabolic process Source: Ensembl
Regulation of calcium ion import Source: BHF-UCL
Regulation of protein localization to cell surface Source: BHF-UCL
Regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
Cellular Location
Membrane
Involvement in disease
Hypomagnesemia 4 (HOMG4):
A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes.
Topology
Extracellular: 23-1032
Helical: 1033-1053
Cytoplasmic: 1054-1207
PTM
O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor).

Anti-EGF antibodies

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Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYE-0539
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CBFYE-0538
Application*: E
Target: EGF
Host: Mouse
Specificity: Human
Clone: CBFYE-0537
Application*: E, IP, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYE-0536
Application*: WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-0535
Application*: E, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse
Clone: CBFYE-0534
Application*: E, IH, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYE-0533
Application*: E, DB, IH
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYE-0530
Application*: E, C, P, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYE-0529
Application*: E, DB, IH
Target: EGF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-0528
Application*: IF, F, IP, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0527
Application*: E, IH, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0526
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0525
Application*: E, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYE-0523
Application*: E, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0522
Application*: WB, IC, IH, IP
Target: EGF
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse
Clone: CBFYE-0520
Application*: C, WB, E, P
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYE-0519
Application*: E, IF, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0515
Application*: WB, IH, N
Target: EGF
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYE-0514
Application*: WB, EC
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0513
Application*: F, N, WB
Target: EGF
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYE-0512
Application*: WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0290
Application*: EC
Target: EGF
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0078-2M13
Application*: WB, P
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0255- 4T32
Application*: WB, F
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M1401E03
Application*: IP
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: EGF-10
Application*: DB, P, E, WB
Target: EGF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: C74B9
Application*: WB, IP
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9D7F11
Application*: E, IH, WB
Target: EGF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3H11L6
Application*: E, IC
Target: EGF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3A8
Application*: E, IC, IF, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP671
Application*: ICC, IHC, IP, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG
Specificity: Pig
Clone: CAP670
Application*: ICC, IHC, IP, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP669
Application*: ICC, IHC, IP, WB
Target: EGF
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CAP668
Application*: ELISA, WB
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0185
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0184
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0183
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0182
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0181
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0180
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0179
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0178
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0177
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E11
Application*: IF
Target: EGF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7C11-G10-H8
Application*: E
Target: EGF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: C10
Application*: WB, ICC, P, IH-F, E, IP, IF, FC
Target: EGF
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 7-1
Application*: WB, ICC, P, IH-F, E, IP, IF, FC
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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