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ACOT11

ACOT11 is a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Full Name

Acyl-CoA Thioesterase 11

Function

Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway.

Biological Process

Acyl-CoA metabolic process
Fatty acid metabolic process
Intracellular signal transduction
Negative regulation of cold-induced thermogenesis
Response to cold
Response to temperature stimulus

Cellular Location

Mitochondrion matrix; Cytoplasm

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Anti-ACOT11 antibodies

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Mouse Anti-ACOT11 Recombinant Antibody (V2-179336) (CBMAB-A0636-YC)

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Target: ACOT11

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: V2-179336

Application*: WB, E, IH, P

Mouse Anti-ACOT11 Recombinant Antibody (V2-179335) (CBMAB-A0635-YC)

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Target: ACOT11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: V2-179335

Application*: WB, IP, IF, E

Mouse Anti-ACOT11 Recombinant Antibody (V2-179334) (CBMAB-A0634-YC)

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Target: ACOT11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-179334

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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