AFP
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Full Name
Alpha Fetoprotein
Alternative Names
Alpha Fetoprotein; Alpha-1-Fetoprotein; Alpha-Fetoglobulin; HPAFP; Alpha-Fetoprotein; AFPD; FETA;
Function
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
Biological Process
Cellular protein metabolic process
Post-translational protein modification
Post-translational protein modification
Cellular Location
Secreted
Involvement in disease
Alpha-fetoprotein deficiency (AFPD): A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development.
Alpha-fetoprotein, hereditary persistence (HPAFP): A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life.
Alpha-fetoprotein, hereditary persistence (HPAFP): A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life.
PTM
Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.
Sulfated.
Sulfated.
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Anti-AFP antibodies
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CompareTarget: AFP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EC9
Application*: WB, P, IF
Target: AFP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-634168
Application*: WB
Target: AFP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: V2-632688
Application*: FC, IF, WB
Target: AFP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-632687
Application*: FC, IF
Target: AFP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: V2-180149
Application*: E, IP, IH, WB
Target: AFP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-180147
Application*: WB, E, IP
Target: AFP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: V2-180140
Application*: WB, IP
Target: AFP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-180098
Application*: E, IF, IP, WB
Target: AFP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: V2-180091
Application*: E, WB
Target: AFP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: V2-163277
Application*: E, IH, WB
Target: AFP
Sensitivity: 0.56 ng/mL
Detection Range: 1-400 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Pig
Assay Type: Sandwich
Reactivity: Pig
Target: AFP
Sensitivity: 0.29 ng/mL
Detection Range: 0.5-150 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Horse
Assay Type: Sandwich
Reactivity: Horse
Target: AFP
Sensitivity: 0.26 ng/mL
Detection Range: 0.5-150 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: Afp
Sensitivity: 0.0025 ng/mL
Detection Range: 0.005-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: AFP
Sensitivity: 0.29 ng/mL
Detection Range: 0.5-200 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: AFP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-609
Tag: His Tag
Target: AFP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-609
Tag: His & AVI Tag
Target: AFP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-609
Tag: hFc Tag
Target: AFP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 8E10
Application*: E, WB
Target: AFP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16G2
Application*: E, WB
Target: AFP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT3
Application*: WB, P, IF, IC
Target: AFP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT138
Application*: WB, E
Target: AFP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2176
Application*: WB
Target: AFP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4562
Application*: IH, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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