AKR1B10

AKR1B10 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
Full Name
Aldo-Keto Reductase Family 1 Member B10
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097).
Biological Process
Cellular detoxification of aldehyde Source: UniProtKB
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process Source: UniProtKB
Farnesol catabolic process Source: UniProtKB
Retinoid metabolic process Source: UniProtKB
Cellular Location
Lysosome; Secreted. Secreted through a lysosome-mediated non-classical pathway.
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Anti-AKR1B10 antibodies

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Rabbit Anti-AKR1B10 Recombinant Antibody (V2-180473) (CBMAB-A1981-YC)

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Target: AKR1B10
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-180473
Application*: WB, IC, IF
Datasheet SDS

Rabbit Anti-AKR1B10 Recombinant Antibody (V2-180472) (CBMAB-A1980-YC)

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Target: AKR1B10
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-180472
Application*: WB, F, IC, IF
Datasheet SDS

Mouse Anti-AKR1B10 Recombinant Antibody (V2-180471) (CBMAB-A1979-YC)

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Target: AKR1B10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-180471
Application*: E
Datasheet SDS

Mouse Anti-AKR1B10 Recombinant Antibody (V2-180470) (CBMAB-A1978-YC)

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Target: AKR1B10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-180470
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-AKR1B10 Recombinant Antibody (V2-180469) (CBMAB-A1977-YC)

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Target: AKR1B10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-180469
Application*: E, IC, IF, P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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