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AKR1B10

AKR1B10 is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.

Full Name

Aldo-Keto Reductase Family 1 Member B10

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:9565553, PubMed:18087047, PubMed:12732097, PubMed:19013440, PubMed:19563777). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097).

Biological Process

Cellular detoxification of aldehyde Source: UniProtKB
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process Source: UniProtKB
Farnesol catabolic process Source: UniProtKB
Retinoid metabolic process Source: UniProtKB

Cellular Location

Lysosome; Secreted. Secreted through a lysosome-mediated non-classical pathway.

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Anti-AKR1B10 antibodies

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Rabbit Anti-AKR1B10 Recombinant Antibody (V2-180473) (CBMAB-A1981-YC)

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Target: AKR1B10

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: V2-180473

Application*: WB, IC, IF

Rabbit Anti-AKR1B10 Recombinant Antibody (V2-180472) (CBMAB-A1980-YC)

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Target: AKR1B10

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: V2-180472

Application*: WB, F, IC, IF

Mouse Anti-AKR1B10 Recombinant Antibody (V2-180471) (CBMAB-A1979-YC)

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Target: AKR1B10

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: V2-180471

Application*: E

Mouse Anti-AKR1B10 Recombinant Antibody (V2-180470) (CBMAB-A1978-YC)

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Target: AKR1B10

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-180470

Application*: E, IF, WB

Mouse Anti-AKR1B10 Recombinant Antibody (V2-180469) (CBMAB-A1977-YC)

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Target: AKR1B10

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: V2-180469

Application*: E, IC, IF, P, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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