ALDH5A1

ALDH5A1 belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabol
Full Name
Aldehyde Dehydrogenase 5 Family Member A1
Function
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Biological Process
Central nervous system development Source: UniProtKB
Gamma-aminobutyric acid catabolic process Source: UniProtKB
Glutamate metabolic process Source: UniProtKB
Neurotransmitter catabolic process Source: UniProtKB
Post-embryonic development Source: Ensembl
Succinate metabolic process Source: UniProtKB
Cellular Location
Mitochondrion
Involvement in disease
Succinic semialdehyde dehydrogenase deficiency (SSADHD): A rare inborn error of 4-aminobutyric acid (GABA) metabolism, which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is clinically characterized by developmental delay, hypotonia, mental retardation, ataxia, seizures, hyperkinetic behavior, aggression, and sleep disturbances.
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Anti-ALDH5A1 antibodies

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Mouse Anti-ALDH5A1 Recombinant Antibody (17F5) (CBMAB-A2299-YC)

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Target: ALDH5A1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 17F5
Application*: WB, E, IC, IF, IH
Datasheet SDS

Rabbit Anti-ALDH5A1 Recombinant Antibody (BA0340) (CBMAB-0059CQ)

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Target: ALDH5A1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: BA0340
Application*: WB, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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