AP1G1

Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

Adaptor Related Protein Complex 1 Gamma 1 Subunit

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025).

Biological Process

Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Endosome to melanosome transport Source: ParkinsonsUK-UCL
Golgi to lysosome transport Source: UniProtKB
Golgi to vacuole transport Source: GO_Central
Intracellular protein transport Source: InterPro
Melanosome organization Source: ParkinsonsUK-UCL
Positive regulation of natural killer cell degranulation Source: UniProtKB
Positive regulation of natural killer cell mediated cytotoxicity Source: UniProtKB
Post-Golgi vesicle-mediated transport Source: Reactome
Receptor-mediated endocytosis Source: GO_Central
Regulation of defense response to virus by virus Source: Reactome

Cellular Location

Cytoplasm; Golgi apparatus; Clathrin-coated vesicle membrane; Perinuclear region; Clathrin-coated vesicle. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (PubMed:12773381). Co-localizes with AFTPH/aftiphilin in the cytoplasm (PubMed:15758025).