ATP9A

ATP9A (ATPase Phospholipid Transporting 9A (Putative)) is a Protein Coding gene. Among its related pathways are Ion channel transport and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include nucleotide binding and cation-transpo

Full Name

ATPase, class II, type 9A

Function

Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling and endosome to trans-Golgi network retrograde transport (PubMed:27733620, PubMed:30213940).
In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation (PubMed:30213940).
Appears to be implicated in intercellular communication by negatively regulating the release of exosomes (PubMed:30947313).
The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved (PubMed:30947313).

Biological Process

Endocytosis Source: GO_Central
Negative regulation of exosomal secretion Source: UniProtKB
Phospholipid translocation Source: GO_Central
Regulation of endocytic recycling Source: UniProtKB
Regulation of retrograde transport, endosome to Golgi Source: UniProtKB
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central

Cellular Location

Early endosome membrane; Recycling endosome membrane; Cell membrane; Trans-Golgi network membrane. Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B (PubMed:21914794). Transiently expressed in the plasma membrane (PubMed:30947313).

Topology

Cytoplasmic: 2-69 aa
Helical: 70-91 aa
Extracellular: 92-96 aa
Helical: 97-119 aa
Cytoplasmic: 120-303 aa
Helical: 304-325 aa
Extracellular: 326-332 aa
Helical: 333-354 aa
Cytoplasmic: 355-841 aa
Helical: 842-862 aa
Extracellular: 863-874 aa
Helical: 875-893 aa
Cytoplasmic: 894-923 aa
Helical: 924-942 aa
Extracellular: 943-949 aa
Helical: 950-972 aa
Cytoplasmic: 973-978 aa
Helical: 979-999 aa
Extracellular: 1000-1006 aa
Helical: 1007-1030 aa
Cytoplasmic: 1031-1047 aa