BCLAF1

This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Full Name

BCL2 Associated Transcription Factor 1

Function

Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

Biological Process

Apoptotic process Source: UniProtKB
Cellular response to leukemia inhibitory factor Source: Ensembl
Negative regulation of transcription, DNA-templated Source: MGI
Positive regulation of apoptotic process Source: MGI
Positive regulation of DNA-templated transcription, initiation Source: UniProtKB
Positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
Positive regulation of response to DNA damage stimulus Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of DNA-templated transcription in response to stress Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus; Nucleus speckle; Nucleoplasm

PTM

Citrullinated by PADI4.