CDK16

CDK16 (Cyclin Dependent Kinase 16) is a protein coding gene. Among its related pathways are DNA Damage and Signal transduction_PKA signaling. Gene Ontology annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK17.
Full Name
Cyclin Dependent Kinase 16
Function
Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity).
Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
Biological Process
Exocytosis Source: UniProtKB
Growth hormone secretion Source: UniProtKB
Neuron projection development Source: UniProtKB
Protein phosphorylation Source: GO_Central
Regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: GO_Central
Spermatogenesis Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasm; Secretory vesicle; Synaptosome. Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.
PTM
Phosphorylation at Ser-153 inhibits kinase activity.
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Anti-CDK16 antibodies

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Mouse Anti-CDK16 Recombinant Antibody (2E5) (CBMAB-A6482-LY)

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Target: CDK16
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E5
Application*: WB, E, IP, IF
Datasheet SDS

Mouse Anti-CDK16 Recombinant Antibody (G6.1) (CBMAB-P0171-YC)

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Target: CDK16
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Frog, Human, Mouse, Rat
Clone: G6.1
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-CDK16 Recombinant Antibody (CBYY-C1756) (CBMAB-C3194-YY)

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Target: CDK16
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C1756
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-CDK16 Recombinant Antibody (C5007) (CBMAB-C5007-LY)

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Target: CDK16
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C5007
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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