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CLINT1

This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Full Name

Clathrin Interactor 1

Function

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly.

Biological Process

Clathrin coat assembly Source: Ensembl
Endocytosis Source: GO_Central
Post-Golgi vesicle-mediated transport Source: Reactome

Cellular Location

Cytoplasm; Perinuclear region; Clathrin-coated vesicle. Found throughout the cell, with the exception of the cell surface. Concentrated in the perinuclear region and associated with clathrin-coated vesicles close to the trans-Golgi network.

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Anti-CLINT1 antibodies

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Mouse Anti-CLINT1 Recombinant Antibody (8B6) (CBMAB-C9060-LY)

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Target: CLINT1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 8B6

Application*: WB

Mouse Anti-CLINT1 Recombinant Antibody (1E6) (CBMAB-C3963-LY)

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Target: CLINT1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1E6

Application*: E, P, WB, IF

Mouse Anti-CLINT1 Recombinant Antibody (CBFYC-1946) (V2LY-1206-LY237)

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Target: CLINT1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBFYC-1946

Application*: WB

Mouse Anti-CLINT1 Recombinant Antibody (6G10) (V2LY-1206-LY235)

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Target: CLINT1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: 6G10

Application*: WB

Mouse Anti-CLINT1 Recombinant Antibody (10F12) (V2LY-1206-LY233)

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Target: CLINT1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 10F12

Application*: WB

Mouse Anti-CLINT1 Recombinant Antibody (CBFYE-0339) (V2LY-1206-LY232)

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Target: CLINT1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-0339

Application*: WB, IP, IF, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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