CRBN

CRBN expression is closely associated with IRF4, which is an important target of IMiD therapy.
Full Name
Cereblon
Function
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed:20223979, PubMed:24328678, PubMed:25043012, PubMed:25108355).

Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons (PubMed:18414909, PubMed:29530986).

Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (PubMed:18414909).

May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity).
Biological Process
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm; Membrane
Involvement in disease
Mental retardation, autosomal recessive 2A (MRT2A):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features.
PTM
Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex.
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Anti-CRBN antibodies

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Rabbit Anti-CRBN Recombinant Antibody (CP0367) (CBMAB-CP0367-LY)

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Target: CRBN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CP0367
Application*: WB, P
Datasheet SDS

Mouse Anti-CRBN Recombinant Antibody (CBYY-C2841) (CBMAB-C4282-YY)

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Target: CRBN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2841
Application*: IH, IF
Datasheet SDS

Mouse Anti-CRBN Recombinant Antibody (C5699) (CBMAB-C5699-LY)

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Target: CRBN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: C5699
Application*: IH, WB
Datasheet SDS

Human Recombinant CRBN & DDB1 protein, Dimer, His & Flag Tag (V2LY-0526-LY3361)

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Target: CRBN
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-442, 2-1140
Tag: His & Flag Tag
Datasheet SDS

Human Recombinant CRBN & DDB1 & CUL4A & RBX1 protein, His Tag (V2LY-0526-LY3358)

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Target: CRBN
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: His Tag
Datasheet SDS

Human Recombinant CRBN & DDB1 protein, Hetero Dimer , His Tag (V2LY-0526-LY3360)

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Target: CRBN
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: His Tag
Datasheet SDS

Human Recombinant CRBN & DDB1 protein, Hetero Dimer , GST Tag (V2LY-0526-LY3359)

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Target: CRBN
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: CRBN (1-442), DDB1 (1-1140)
Tag: GST Tag
Datasheet SDS

Human Recombinant CRBN protein, GST Tag (V2LY-0526-LY3362)

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Target: CRBN
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-442
Tag: GST Tag
Datasheet SDS

Rabbit Anti-CRBN Recombinant Antibody (AP1688) (V2LY-1206-LY1080)

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Target: CRBN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: AP1688
Application*: WB, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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