CTTN

CTTN (Cortactin) is a Protein Coding gene. Diseases associated with CTTN include Ethmoid Sinus Adenocarcinoma and Ethmoid Sinus Cancer. Among its related pathways are N-cadherin signaling events and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include profilin binding. An important paralog of this gene is HCLS1.

Cortactin

Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879).

Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity).

Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity).

Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290).

Plays a role in focal adhesion assembly and turnover (By similarity).

In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316).

Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782).

Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity).

Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).

Actin cytoskeleton reorganization Source: UniProtKB
Actin filament polymerization Source: InterPro
Cell motility Source: UniProtKB
Dendritic spine maintenance Source: Ensembl
Focal adhesion assembly Source: UniProtKB
Intracellular protein transport Source: UniProtKB
Lamellipodium organization Source: UniProtKB
Membrane organization Source: Reactome
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Neuron projection morphogenesis Source: UniProtKB
Positive regulation of actin filament polymerization Source: UniProtKB
Positive regulation of smooth muscle contraction Source: UniProtKB
Receptor-mediated endocytosis Source: UniProtKB
Regulation of actin filament polymerization Source: GO_Central
Regulation of autophagy of mitochondrion Source: Ensembl
Regulation of axon extension Source: UniProtKB
Substrate-dependent cell migration, cell extension Source: Ensembl

Cell membrane; Cytoskeleton; Lamellipodium; Ruffle; Dendrite; Cell projection; Podosome; Cell junction; Focal adhesion; Clathrin-coated pit; Dendritic spine; Cell cortex. Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity).

Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.