DFFB

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.
Full Name
DNA Fragmentation Factor Subunit Beta
Function
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Biological Process
Apoptotic chromosome condensation Source: UniProtKB
Apoptotic DNA fragmentation Source: CAFA
DNA catabolic process Source: CAFA
Cellular Location
Nucleus; Cytoplasm
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Anti-DFFB antibodies

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Mouse Anti-DFFB Recombinant Antibody (CBYCD-248) (CBMAB-D0759-YC)

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Target: DFFB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYCD-248
Application*: WB
Datasheet SDS

Mouse Anti-DFFB Recombinant Antibody (CBYCD-247) (CBMAB-D0758-YC)

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Target: DFFB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYCD-247
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DFFB Recombinant Antibody (D0757) (CBMAB-D0757-YC)

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Target: DFFB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: D0757
Application*: WB
Datasheet SDS

Mouse Anti-DFFB Recombinant Antibody (D0756) (CBMAB-D0756-YC)

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Target: DFFB
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: D0756
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DFFB Recombinant Antibody (4H79) (CBMAB-D0753-YC)

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Target: DFFB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 4H79
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DFFB Recombinant Antibody (CBT3705) (V2LY-0625-LY1306)

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Target: DFFB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3705
Application*: IH, F
Datasheet SDS

Mouse Anti-DFFB Recombinant Antibody (CBT3596) (V2LY-0625-LY1280)

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Target: DFFB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3596
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-DFFB Recombinant Antibody (CBYCD-246) (V2LY-0425-LY222)

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Target: DFFB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCD-246
Application*: WB, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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