DRD1

This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

Full Name

Dopamine Receptor D1

Function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Biological Process

Activation of adenylate cyclase activity Source: BHF-UCL
Adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
Adenylate cyclase-activating dopamine receptor signaling pathway Source: UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Adult walking behavior Source: BHF-UCL
Cellular response to catecholamine stimulus Source: BHF-UCL
Cellular response to dopamine Source: CAFA
Cerebral cortex GABAergic interneuron migration Source: BHF-UCL
Dopamine metabolic process Source: BHF-UCL
Dopamine receptor signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: BHF-UCL
Mating behavior Source: BHF-UCL
Phospholipase C-activating dopamine receptor signaling pathway Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: BHF-UCL
Positive regulation of gene expression Source: CAFA
Positive regulation of potassium ion transport Source: BHF-UCL
Positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
Positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
Prepulse inhibition Source: BHF-UCL
Regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
Response to drug Source: BHF-UCL
Synapse assembly Source: BHF-UCL
Transmission of nerve impulse Source: BHF-UCL
Vasodilation Source: InterPro
Visual learning Source: BHF-UCL

Cellular Location

Endoplasmic reticulum membrane; Cell membrane; Dendrite; Dendritic spine. Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.

Topology

Extracellular: 1-23
Helical: 24-49
Cytoplasmic: 50-60
Helical: 61-87
Extracellular: 88-96
Helical: 97-119
Cytoplasmic: 120-138
Helical: 139-163
Extracellular: 164-192
Helical: 193-218
Cytoplasmic: 219-272
Helical: 273-299
Extracellular: 300-312
Helical: 313-337
Cytoplasmic: 338-446