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ENG

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Full Name
Endoglin
Research Area
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529).

Required for normal structure and integrity of adult vasculature (PubMed:7894484).

Regulates the migration of vascular endothelial cells (PubMed:17540773).

Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity).

May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity).

May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830).

Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529).

Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
Biological Process
Angiogenesis Source: GO_Central
Artery morphogenesis Source: BHF-UCL
Atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
Atrioventricular canal morphogenesis Source: BHF-UCL
BMP signaling pathway Source: BHF-UCL
Bone development Source: Ensembl
Branching involved in blood vessel morphogenesis Source: BHF-UCL
Cardiac atrium morphogenesis Source: BHF-UCL
Cardiac ventricle morphogenesis Source: BHF-UCL
Cell adhesion Source: UniProtKB-KW
Cell chemotaxis Source: BHF-UCL
Cell migration Source: BHF-UCL
Cell migration involved in endocardial cushion formation Source: Ensembl
Cell motility Source: BHF-UCL
Cellular response to mechanical stimulus Source: Ensembl
Central nervous system vasculogenesis Source: BHF-UCL
Detection of hypoxia Source: BHF-UCL
Dorsal aorta morphogenesis Source: BHF-UCL
Endocardial cushion morphogenesis Source: BHF-UCL
Epithelial to mesenchymal transition Source: GO_Central
Epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
Extracellular matrix constituent secretion Source: Ensembl
Extracellular matrix disassembly Source: BHF-UCL
Heart looping Source: BHF-UCL
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of endothelial cell proliferation Source: BHF-UCL
Negative regulation of gene expression Source: BHF-UCL
Negative regulation of nitric-oxide synthase activity Source: BHF-UCL
Negative regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Negative regulation of protein autophosphorylation Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Outflow tract septum morphogenesis Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of BMP signaling pathway Source: BHF-UCL
Positive regulation of collagen biosynthetic process Source: Ensembl
Positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of systemic arterial blood pressure Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of vascular associated smooth muscle cell differentiation Source: BHF-UCL
Regulation of cell adhesion Source: BHF-UCL
Regulation of cell population proliferation Source: BHF-UCL
Regulation of phosphorylation Source: BHF-UCL
Regulation of transcription, DNA-templated Source: HGNC-UCL
Regulation of transforming growth factor beta receptor signaling pathway Source: HGNC-UCL
Response to corticosteroid Source: Ensembl
Response to drug Source: Ensembl
Response to hypoxia Source: BHF-UCL
Smooth muscle tissue development Source: BHF-UCL
Transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Vascular associated smooth muscle cell development Source: BHF-UCL
Vasculogenesis Source: BHF-UCL
Venous blood vessel morphogenesis Source: BHF-UCL
Ventricular trabecula myocardium morphogenesis Source: BHF-UCL
Wound healing Source: BHF-UCL
Cellular Location
Cell membrane
Involvement in disease
Telangiectasia, hereditary hemorrhagic, 1 (HHT1):
A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. The disease is characterized by recurrent epistaxis and gastro-intestinal hemorrhage. Visceral involvement includes arteriovenous malformations of the lung, liver, and brain.
Topology
Extracellular: 26-586
Helical: 587-611
Cytoplasmic: 612-658

Anti-ENG antibodies

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Target: ENG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CAP692
Application*: ICC, IHC, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP691
Application*: ICC, IHC, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CB102A
Application*: ELISA, IHC
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB187
Application*: IF, FC
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB186
Application*: IF, FC
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB185
Application*: IF, FC
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb213
Application*: FC, IHC-F, Immuno assays, IP, WB
Target: ENG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBHb084
Application*: FC, IHC-F, Immuno assays, IF, IP, IHC-P, WB
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D50G1
Application*: WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: O99E5
Application*: WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: N1-3A1
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0141
Application*: F, C, IA, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8H109
Application*: FC, IF
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1805
Application*: FC, IH, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3609
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3608
Application*: IF, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2116
Application*: IC, F
Target: ENG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-0645
Application*: E, IC, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0642
Application*: F, IH, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: E9
Application*: F, FN, C, P, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SN6/N1-3A1
Application*: F, FN, IH
Target: ENG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1398
Application*: F, IH, IP, WB
Target: ENG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-0641
Application*: IH, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-0643
Application*: F, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-0644
Application*: F, IH, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SN6h
Application*: F, P, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2885
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2430
Application*: F, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2429
Application*: WB
Target: ENG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C2428
Application*: IH, P, WB
Target: ENG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-2606
Application*: F, IC, IF, C, WB
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2605
Application*: F
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2604
Application*: E, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2603
Application*: WB, P, C, F
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2602
Application*: WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBFYC-2601
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0487
Application*: F, C, IH, IP
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0863
Application*: WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0862
Application*: E, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0861
Application*: F, IH, IP
Target: ENG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey, Mouse
Clone: CBFYE-0860
Application*: WB, IF
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0859
Application*: WB, IH, IF
Target: ENG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBFYE-0858
Application*: E, F, IC, IH, IP, WB
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYE-0857
Application*: E, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-0065
Application*: F
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0061
Application*: F, IF
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYE-0054
Application*: WB, E, F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SN6
Application*: WB, F, IH, IP, C
Target: ENG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: RM0030-6J9
Application*: WB, IH, P
Target: ENG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: MEM-226
Application*: WB, F, IP, F, MC
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 166707
Application*: F, MC
Target: ENG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 209701
Application*: F, IH, IC, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig
Clone: MEM-229
Application*: F, IC, IF, IH, C, IF, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 3A9
Application*: E, IC, IF, P, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: MJ7/18
Application*: F, IF, IH, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: P4A4
Application*: WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2427
Application*: IF, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2426
Application*: E, F, IH, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2425
Application*: P
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2424
Application*: E, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2423
Application*: IF, P, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2421
Application*: F, IH, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2420
Application*: IF, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0710
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0651
Application*: E, F, IH
Target: ENG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C0257
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0151
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0038
Application*: WB, IF
Target: ENG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8J232
Application*: F, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8B8
Application*: WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Dog, Human, Monkey
Clone: 8A1
Application*: WB, F, IC/IF
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7H217
Application*: F, IH
Target: ENG
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6J9
Application*: IH, P, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G8
Application*: IF, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A517
Application*: E, F, IH, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4G11
Application*: P
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H5
Application*: IF, P, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3G4A6
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F106
Application*: F, C, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3D5
Application*: IF, WB
Target: ENG
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 2Q1707
Application*: F, IH, IP, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 1G2
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B111
Application*: E, F, C, WB
Target: ENG
Host: rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10E14D50G1
Application*: WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 105C02
Application*: WB, P, C, F
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 103
Application*: F
Target: ENG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1
Application*: E, WB
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 43A3
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 35/CD105
Application*: WB, IF
Target: ENG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 266
Application*: F, C, IH, IP
Target: ENG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B4-G8
Application*: F
Target: ENG
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3A9
Application*: WB, IHC, IF, FC, ELISA
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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