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ERP44

This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

Full Name

Endoplasmic Reticulum Protein 44

Research Area

Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.

Biological Process

Cell redox homeostasis Source: UniProtKB
Glycoprotein metabolic process Source: UniProtKB
Protein folding Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Response to unfolded protein Source: UniProtKB

Cellular Location

Endoplasmic reticulum lumen

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Anti-ERP44 antibodies

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Mouse Anti-ERP44 Recombinant Antibody (3C7) (CBMAB-A9678-LY)

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Target: ERP44

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3C7

Application*: WB, E, IP, IH

Human ERP44 ELISA Kit (V2LY-0626-LY4541)

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Target: ERP44

Sensitivity: 0.0093 ng/mL

Detection Range: 0.02-4.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human Recombinant ERP44 protein, His Tag (V2LY-0526-LY3955)

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Target: ERP44

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-402

Tag: His Tag

Rabbit Anti-ERp44 Recombinant Antibody (CBFYE-1208) (V2LY-0825-LY742)

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Target: ERp44

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: CBFYE-1208

Application*: WB, IH

Mouse Anti-ERP44 Recombinant Antibody (CBFYE-1207) (V2LY-0825-LY741)

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Target: ERP44

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-1207

Application*: WB, IP, IF, E

Mouse Anti-ERP44 Recombinant Antibody (CBFYE-0258) (V2LY-0825-LY740)

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Target: ERP44

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-0258

Application*: WB, IP, IF, E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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