GPR39

This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression.

Full Name

G protein-coupled receptor 39

Function

Zn2+ acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).

Biological Process

G protein-coupled receptor signaling pathway Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-34
Helical: 35-55
Cytoplasmic: 56-69
Helical: 70-89
Extracellular: 90-109
Helical: 110-131
Cytoplasmic: 132-151
Helical: 152-172
Extracellular: 173-217
Helical: 218-242
Cytoplasmic: 243-283
Helical: 284-305
Extracellular: 306-323
Helical: 324-344
Cytoplasmic: 345-453