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Mouse Anti-GPR39 Recombinant Antibody (CBFYH-0459) (CBMAB-H0369-FY)

This product is mouse antibody that recognizes GPR39. The antibody CBFYH-0459 can be used for immunoassay techniques such as: FC.
See all GPR39 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0459
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
G protein-coupled receptor 39
Introduction
This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression.
Entrez Gene ID
2863
UniProt ID
O43194
Alternative Names
G Protein-Coupled Receptor 39
Function
Zn2+ acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).
Biological Process
G protein-coupled receptor signaling pathway Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-34
Helical: 35-55
Cytoplasmic: 56-69
Helical: 70-89
Extracellular: 90-109
Helical: 110-131
Cytoplasmic: 132-151
Helical: 152-172
Extracellular: 173-217
Helical: 218-242
Cytoplasmic: 243-283
Helical: 284-305
Extracellular: 306-323
Helical: 324-344
Cytoplasmic: 345-453

Chen, Q., & Lou, Y. (2023). G protein-coupled receptor 39 alleviates mitochondrial dysfunction and hepatocyte lipid accumulation via SIRT1/Nrf2 signaling. Journal of Bioenergetics and Biomembranes, 55(1), 33-42.

Cao, B., Wang, J., & Feng, J. (2023). Signaling pathway mechanisms of neurological diseases induced by G protein‐coupled receptor 39. CNS Neuroscience & Therapeutics.

Chen, L., Fang, Z., Wang, X., Sun, X., Ge, X., Cheng, C., & Hu, H. (2021). G protein-coupled receptor 39 activation alleviates oxidized low-density lipoprotein-induced macrophage inflammatory response, lipid accumulation and apoptosis by inducing A20 expression. Bioengineered, 12(1), 4070-4080.

Liao, H., Gao, W., Ma, J., Xue, H., Wang, Y., Huang, D., ... & Ye, Y. (2021). GPR39 promotes cardiac hypertrophy by regulating the AMPK–mTOR pathway and protein synthesis. Cell Biology International, 45(6), 1211-1219.

Satianrapapong, W., Pongkorpsakol, P., & Muanprasat, C. (2020). A G-protein coupled receptor 39 agonist stimulates proliferation of keratinocytes via an ERK-dependent pathway. Biomedicine & Pharmacotherapy, 127, 110160.

Goto, K., Nishitsuji, H., Sugiyama, M., Nishida, N., Mizokami, M., & Shimotohno, K. (2020). Orchestration of intracellular circuits by g protein-coupled receptor 39 for hepatitis b virus proliferation. International journal of molecular sciences, 21(16), 5661.

Cuzon Carlson, V. C., Ford, M. M., Carlson, T. L., Lomniczi, A., Grant, K. A., Ferguson, B., & Cervera-Juanes, R. P. (2019). Modulation of Gpr39, a G-protein coupled receptor associated with alcohol use in non-human primates, curbs ethanol intake in mice. Neuropsychopharmacology, 44(6), 1103-1113.

Muneoka, S., Goto, M., Nishimura, T., Enomoto, K., Kadoshima-Yamaoka, K., & Tomimori, Y. (2019). G protein-coupled receptor 39 agonist improves Concanavalin A-induced hepatitis in mice. Biological and Pharmaceutical Bulletin, 42(8), 1415-1418.

Muneoka, S., Goto, M., Kadoshima-Yamaoka, K., Kamei, R., Terakawa, M., & Tomimori, Y. (2018). G protein-coupled receptor 39 plays an anti-inflammatory role by enhancing IL-10 production from macrophages under inflammatory conditions. European journal of pharmacology, 834, 240-245.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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