loading...

GPRC5A

This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.

Full Name

G protein-coupled receptor class C group 5 member A

Function

Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity).

May act as a lung tumor suppressor (PubMed:18000218).

Biological Process

Negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cell membrane; Cytoplasmic vesicle membrane. Localized in perinuclear vesicles, probably Golgi-associated vesicles.

Topology

Extracellular: 1-33
Helical: 34-54
Cytoplasmic: 55-68
Helical: 69-89
Extracellular: 90-97
Helical: 98-118
Cytoplasmic: 119-129
Helical: 130-150
Extracellular: 151-176
Helical: 177-197
Cytoplasmic: 198-212
Helical: 213-233
Extracellular: 234-247
Helical: 248-268
Cytoplasmic: 269-357

PTM

Phosphorylated in two conserved double-tyrosine motifs, TYR-317/TYR-320 and TYR-347/TYR-350, by EGFR; leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. TYR-317 and TYR-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation.

View more

Anti-GPRC5A antibodies

+ Filters

Loading...

Mouse Anti-GPRC5A Recombinant Antibody (6) (CBMAB-G0726-LY)

Compare

Target: GPRC5A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: 6

Application*: E, IP, IF, WB

Mouse Anti-GPRC5A Recombinant Antibody (G4684) (V2LY-0226-LY913)

Compare

Target: GPRC5A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: G4684

Application*: E, IP, IF, WB

Mouse Anti-GPRC5A Recombinant Antibody (EG1287) (V2LY-0226-LY910)

Compare

Target: GPRC5A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: EG1287

Application*: IH

Mouse Anti-GPRC5A Recombinant Antibody (CBFYH-0461) (V2LY-0226-LY909)

Compare

Target: GPRC5A

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYH-0461

Application*: F, WB

Mouse Anti-GPRC5A Recombinant Antibody (EG1412) (CBMAB-EN1691-LY)

Compare

Target: GPRC5A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: EG1412

Application*: E, IP, IF, WB

Rabbit Anti-GPRC5A Recombinant Antibody (7D) (CBMAB-R0536-CN)

Compare

Target: GPRC5A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 7D

Application*: WB

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry