HBG1

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

Hemoglobin Subunit Gamma 1

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Cellular oxidant detoxification Source: GOC
Hydrogen peroxide catabolic process Source: GO_Central

Cytosol; Hemoglobin complex; Haptoglobin-hemoglobin complex

Acetylation of Gly-2 converts Hb F to the minor Hb F1.