KDELR3

This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Full Name

Kdel Endoplasmic Reticulum Protein Retention Receptor 3

Function

Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

Biological Process

Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Protein retention in ER lumenManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Endoplasmic reticulum membrane; Golgi apparatus membrane; Cytoplasmic vesicle, COPI-coated vesicle membrane. Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.

Topology

Lumenal: 1-4
Helical: 5-24
Cytoplasmic: 25-32
Helical: 33-52
Lumenal: 53-58
Helical: 59-79
Cytoplasmic: 80-92
Helical: 93-110
Lumenal: 111-116
Helical: 117-135
Cytoplasmic: 136-149
Helical: 150-168
Lumenal: 169-178
Helical: 179-199
Cytoplasmic: 200-214