KDM4C

This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants.
Full Name
KDM4C
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Biological Process
Blastocyst formationIEA:Ensembl
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K36 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K9 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of histone H3-K9 trimethylationIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of androgen receptor signaling pathwayTAS:Reactome
Regulation of stem cell differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Stem cell population maintenanceIEA:Ensembl
Cellular Location
Nucleus
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Anti-KDM4C antibodies

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Mouse Anti-KDM4C Recombinant Antibody (CBYJL-035) (CBMAB-L0065-YJ)

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Target: KDM4C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-035
Application*: WB, IH, IC, IF, P
Datasheet SDS

Human Recombinant KDM4C protein, GST Tag (V2LY-0526-LY5145)

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Target: KDM4C
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-460
Tag: GST Tag
Datasheet SDS

Mouse Anti-KDM4C Recombinant Antibody (8A1) (CBMAB-K0694-LY)

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Target: KDM4C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8A1
Application*: P, WB
Datasheet SDS

Mouse Anti-KDM4C Recombinant Antibody (5B9) (CBMAB-K0693-LY)

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Target: KDM4C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B9
Application*: IC/IF, P, WB
Datasheet SDS

Mouse Anti-KDM4C Recombinant Antibody (4B1) (CBMAB-K0692-LY)

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Target: KDM4C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B1
Application*: F, IF, P
Datasheet SDS

Mouse Anti-KDM4C Recombinant Antibody (D-4) (CBMAB-0318-WJ)

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Target: KDM4C
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: D-4
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-KDM4C Recombinant Antibody (1B10) (CBMAB-0681-CN)

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Target: KDM4C
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B10
Application*: E, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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