KLRB1
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Full Name
Killer Cell Lectin Like Receptor B1
Function
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Cytoplasmic: 1-44
Helical: 45-66
Extracellular: 67-225
Helical: 45-66
Extracellular: 67-225
PTM
N-glycosylated. Contains sialic acid residues.
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Anti-KLRB1 antibodies
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CompareTarget: KLRB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: 1C10
Application*: F, IP, WB
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP915
Application*: WB
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 702228
Application*: F, MC
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 6A381
Application*: F, IH, IP
Target: KLRB1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 694370
Application*: F, MC
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 3F8
Application*: C, WB
Target: KLRB1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: 3B3
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: 3.2.3
Application*: F
Target: KLRB1
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: 15H14
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3H1911 B199.2
Application*: F, IH, IP
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 28764
Application*: WB, C, P, F, R
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 27302
Application*: F, C, IP, R, WB
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 10-78
Application*: F, C
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3812
Application*: F
Target: KLRB1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: A1366
Application*: FC
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3963
Application*: WB
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3961
Application*: F
Target: KLRB1
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: CBWJC-3959
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: B-D51
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2265
Application*: F, C
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXC-1572
Application*: IH, WB
Target: KLRB1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1290
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2460
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1294
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2418
Application*: WB, IH, P
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-C0528
Application*: F, IP, IA, WB, IH
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-0494
Application*: F, C, IP, R, WB
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0294
Application*: WB, P
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-0156
Application*: F, C
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYC-0145
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-0083
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBWJN-0349
Application*: F, IH
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBWJN-0907
Application*: F, IH, IP, C
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: Okt78
Application*: R, C, IP, F, WB
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2F3
Application*: E, WB
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D8
Application*: WB, IH
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 14F2F11
Application*: WB
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 14F1F11
Application*: WB, IH, P
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ABM2D74
Application*: IH, WB
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B199.2
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: HP-3G10
Application*: F
Target: KLRB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 10/78
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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