LGALS7
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq]
Full Name
lectin, galactoside-binding, soluble, 7
Function
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of CD4-positive, alpha-beta T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of CD4-positive, alpha-beta T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of interferon-gamma productionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Secreted
May be secreted by a non-classical secretory pathway.
Nucleus
Secreted
May be secreted by a non-classical secretory pathway.
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Anti-LGALS7 antibodies
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CompareTarget: LGALS7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: 32
Application*: ICC, IHC, IP, WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6B5
Application*: WB, E
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2374
Application*: IC, C/P, E (IA), WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-2373
Application*: IC, C/P, E (IA), WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: MM0301-3Z10
Application*: WB
Target: LGALS7
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 8J52
Application*: IH, WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: 15j88
Application*: E, IC, IH, WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 15j87
Application*: E, IC, IH, WB
Target: LGALS7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3079
Application*: IC/IF
Target: LGALS7
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0083-8J52
Application*: WB
Target: LGALS7
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L457
Application*: IH, WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 950756
Application*: WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 950723
Application*: WB
Target: LGALS7
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 212923
Application*: WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 198614
Application*: WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-275
Application*: E, WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-274
Application*: E, WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-273
Application*: WB, IC, P, C, E
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-272
Application*: WB, IC, P, C, E
Target: Lgals7
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2411
Application*: WB
Target: LGALS7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1532
Application*: WB, IP, P, IC
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJL-1531
Application*: E, WB
Target: LGALS7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2629
Application*: F
Target: LGALS7
Expressed Host: E. coli
Sequence: Amino Acid: 2-136
Tag: His Tag
Target: LGALS7
Expressed Host: E. coli
Sequence: Amino Acid: 2-136
Tag: GST Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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