MGRN1

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]

Mahogunin Ring Finger 1

E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).

Endosome to lysosome transport Source: UniProtKB
Negative regulation of cAMP-mediated signaling Source: UniProtKB
Negative regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of smoothened signaling pathway Source: UniProtKB
Protein monoubiquitination Source: UniProtKB
Protein polyubiquitination Source: Ensembl
Protein ubiquitination Source: GO_Central

Endosome
Early endosome
Note: The endosomal localization is dependent on the interaction with TSG101.
Isoform 1:
Nucleus
cytosol
Note: Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
Isoform 2:
Nucleus
cytosol
Note: Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
Isoform 3:
Plasma membrane
Cell membrane
cytosol
Isoform 4:
Plasma membrane
Cell membrane
cytosol

Autoubiquitinated in vitro.