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MGRN1

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
Full Name
Mahogunin Ring Finger 1
Function
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).
Biological Process
Endosome to lysosome transport Source: UniProtKB
Negative regulation of cAMP-mediated signaling Source: UniProtKB
Negative regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of smoothened signaling pathway Source: UniProtKB
Protein monoubiquitination Source: UniProtKB
Protein polyubiquitination Source: Ensembl
Protein ubiquitination Source: GO_Central
Cellular Location
Endosome
Early endosome
Note: The endosomal localization is dependent on the interaction with TSG101.
Isoform 1:
Nucleus
cytosol
Note: Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
Isoform 2:
Nucleus
cytosol
Note: Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
Isoform 3:
Plasma membrane
Cell membrane
cytosol
Isoform 4:
Plasma membrane
Cell membrane
cytosol
PTM
Autoubiquitinated in vitro.
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Anti-MGRN1 antibodies

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MGRN1 Matched Antibody Pair (734) (APMAB-734LY)

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Target: MGRN1
Specificity: Human
Datasheet SDS

MGRN1 Matched Antibody Pair (733) (APMAB-733LY)

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Target: MGRN1
Specificity: Human
Datasheet SDS

Mouse Anti-MGRN1 Recombinant Antibody (3E1) (CBMAB-A5473-LY)

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Target: MGRN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E1
Application*: WB, E
Datasheet SDS

Mouse Anti-MGRN1 (AA 477-576) Recombinant Antibody (CBFYM-2189) (CBMAB-M2371-FY)

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Target: MGRN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2189
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-MGRN1 Recombinant Antibody (CBFYM-0638) (CBMAB-M0773-FY)

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Target: MGRN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0638
Application*: E, WB
Datasheet SDS

Mouse Anti-MGRN1 Recombinant Antibody (CBCNR-587) (CBMAB-R0585-CN)

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Target: MGRN1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNR-587
Application*: WB
Datasheet SDS

Mouse Anti-MGRN1 Recombinant Antibody (3C3) (CBMAB-R0584-CN)

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Target: MGRN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 3C3
Application*: WB, F, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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