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NAPRT

Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]
Full Name
Nicotinate Phosphoribosyltransferase
Function
Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198).

Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275).
Biological Process
NAD salvage Source: GO_Central
Response to oxidative stress Source: UniProtKB
Cellular Location
Cytosol
PTM
Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
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Anti-NAPRT antibodies

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Mouse Anti-NAPRT Recombinant Antibody (D-8) (CBMAB-N1171-WJ)

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Target: NAPRT
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: D-8
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NAPRT Recombinant Antibody (CBWJN-0580) (CBMAB-N1170-WJ)

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Target: NAPRT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0580
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-NAPRT Recombinant Antibody (4A9) (CBMAB-N1169-WJ)

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Target: NAPRT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A9
Application*: E, WB
Datasheet SDS

Mouse Anti-NAPRT Recombinant Antibody (CF302) (CBMAB-FT201LY)

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Target: NAPRT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CF302
Application*: ELISA, WB, IHC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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