NDEL1

This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X.

Full Name

NudE Neurodevelopment Protein 1 Like 1

Function

Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).

Biological Process

Activation of GTPase activity Source: Ensembl
Cell migration Source: GO_Central
Central nervous system neuron axonogenesis Source: Ensembl
Centrosome localization Source: GO_Central
Cerebral cortex radially oriented cell migration Source: Ensembl
Chromosome segregation Source: UniProtKB
Establishment of chromosome localization Source: GO_Central
Establishment of mitotic spindle orientation Source: GO_Central
Inner cell mass cell proliferation Source: Ensembl
Insulin receptor signaling pathway Source: Ensembl
Lysosome localization Source: UniProtKB
Microtubule nucleation Source: GO_Central
Mitotic centrosome separation Source: GO_Central
Neurofilament cytoskeleton organization Source: Ensembl
Neuron migration Source: Ensembl
Neuron projection extension Source: Ensembl
Nuclear membrane disassembly Source: Ensembl
Positive regulation of axon extension Source: Ensembl
Positive regulation of axon regeneration Source: Ensembl
Positive regulation of GTPase activity Source: CACAO
Positive regulation of ruffle assembly Source: UniProtKB
Regulation of intracellular protein transport Source: CACAO
Regulation of neuron projection development Source: GO_Central
Retrograde axonal transport Source: Ensembl
Vesicle transport along microtubule Source: GO_Central

Cellular Location

Cytoskeleton
Centrosome
Spindle
Other locations
Kinetochore
Note: Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the kinetochore in a CENPF-dependent manner.

PTM

Phosphorylated in mitosis. Can be phosphorylated by CDK1, CDK5 and MAPK1. Phosphorylation by CDK5 promotes interaction with KATNA1 and YWHAE.
Palmitoylation at Cys-273 reduces affinity for dynein.