NT5C

This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene.

Full Name

5', 3'-Nucleotidase, Cytosolic

Function

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

Biological Process

Allantoin metabolic processIEA:Ensembl
dCMP catabolic processIEA:Ensembl
DephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
dGMP catabolic processIEA:Ensembl
dTMP catabolic processIEA:Ensembl
dUMP catabolic processIEA:Ensembl
IMP catabolic processIEA:Ensembl
Pyrimidine deoxyribonucleotide catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
UMP catabolic processIEA:Ensembl

Cellular Location

Cytoplasm