NUDT19

Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).

Full Name

Nudix Hydrolase 19

Function

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity).
Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity).
Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (By similarity).
Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).

Biological Process

Butyryl-CoA catabolic processISS:UniProtKB
Coenzyme A catabolic processISS:UniProtKB
Fatty acid catabolic processTAS:Reactome
Malonyl-CoA catabolic processISS:UniProtKB
Medium-chain fatty-acyl-CoA catabolic processISS:UniProtKB
Propionyl-CoA metabolic processISS:UniProtKB
Succinyl-CoA catabolic processISS:UniProtKB

Cellular Location

Peroxisome