OR5B12

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Full Name

Olfactory Receptor Family 5 Subfamily B Member 12

Function

Odorant receptor.

Biological Process

G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Sensory perception of smellManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-23
Helical: 24-44
Cytoplasmic: 45-52
Helical: 53-73
Extracellular: 74-97
Helical: 98-118
Cytoplasmic: 119-137
Helical: 138-158
Extracellular: 159-194
Helical: 195-215
Cytoplasmic: 216-235
Helical: 236-256
Extracellular: 257-269
Helical: 270-290
Cytoplasmic: 291-314