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PFDN2

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq]

Full Name

prefoldin subunit 2

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Biological Process

Negative regulation of amyloid fibril formationManual Assertion Based On ExperimentIDA:FlyBase
Positive regulation of cytoskeleton organizationManual Assertion Based On ExperimentIDA:AgBase
Protein foldingManual Assertion Based On ExperimentIDA:FlyBase
Protein stabilization3 PublicationsIC:ComplexPortal

Cellular Location

Nucleus
Cytoplasm
Mitochondrion

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Anti-PFDN2 antibodies

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Mouse Anti-PFDN2 Recombinant Antibody (CBYC-P306) (CBMAB-P1501-YC)

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Target: PFDN2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYC-P306

Application*: IF, E, WB

Mouse Anti-PFDN2 Recombinant Antibody (2C1) (CBMAB-P1500-YC)

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Target: PFDN2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2C1

Application*: E, IF, WB

Human Recombinant PFDN2 protein, His Tag (V2LY-0526-LY6119)

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Target: PFDN2

Expressed Host: E. coli

Sequence: Amino Acid: 1-154

Tag: His Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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