PFDN2

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq]

prefoldin subunit 2

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Negative regulation of amyloid fibril formationManual Assertion Based On ExperimentIDA:FlyBase
Positive regulation of cytoskeleton organizationManual Assertion Based On ExperimentIDA:AgBase
Protein foldingManual Assertion Based On ExperimentIDA:FlyBase
Protein stabilization3 PublicationsIC:ComplexPortal

Nucleus
Cytoplasm
Mitochondrion