PLAUR (D2 domain)

Full Name

PLAUR (D2 domain)

Function

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.

Biological Process

Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of DNA bindingManual Assertion Based On ExperimentIDA:CACAO
Positive regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of homotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIMP:CACAO
Regulation of cell adhesionManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of fibrinolysis1 PublicationIC:ComplexPortal
Regulation of plasminogen activation1 PublicationIC:ComplexPortal
Regulation of proteolysis1 PublicationNAS:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Urokinase plasminogen activator signaling pathway1 PublicationIC:ComplexPortal

Cellular Location

Cell membrane
Cell projection, invadopodium membrane
Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner.
Isoform 1
Cell membrane
Isoform 2
Secreted