PPARG

PPARG is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity,

peroxisome proliferator activated receptor gamma

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
(Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.

Activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
BMP signaling pathwayManual Assertion Based On ExperimentIGI:BHF-UCL
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cell fate commitmentISS:BHF-UCL
Cell maturationManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to hypoxiaBy SimilarityISS:BHF-UCL
Cellular response to insulin stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to low-density lipoprotein particle stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Epithelial cell differentiationISS:BHF-UCL
Fatty acid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Glucose homeostasisManual Assertion Based On ExperimentIMP:BHF-UCL
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Innate immune responseManual Assertion Based On ExperimentTAS:BHF-UCL
Lipid homeostasisManual Assertion Based On ExperimentTAS:BHF-UCL
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Lipoprotein transportManual Assertion Based On ExperimentIDA:BHF-UCL
Long-chain fatty acid transportISS:BHF-UCL
Macrophage derived foam cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Monocyte differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
mRNA transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of blood vessel endothelial cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of BMP signaling pathwayManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of cardiac muscle hypertrophy in response to stressBy SimilarityISS:BHF-UCL
Negative regulation of cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of cholesterol storageManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of connective tissue replacement involved in inflammatory response wound healingBy SimilarityISS:BHF-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of interferon-gamma-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of lipid storageBy SimilarityISS:BHF-UCL
Negative regulation of macrophage derived foam cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of miRNA-mediated gene silencingManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of mitochondrial fissionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of receptor signaling pathway via STATManual Assertion Based On ExperimentIDA:ARUK-UCL
Negative regulation of sequestering of triglycerideManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of signaling receptor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of SMAD protein signal transductionManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription, DNA-templatedISS:BHF-UCL
Negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of vascular associated smooth muscle cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of vascular endothelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Peroxisome proliferator activated receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Placenta developmentISS:BHF-UCL
Positive regulation of adiponectin secretionBy SimilarityISS:BHF-UCL
Positive regulation of adipose tissue development1 PublicationIC:ComplexPortal
Positive regulation of cholesterol effluxManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of DNA bindingManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of fat cell differentiationBy SimilarityISS:HGNC-UCL
Positive regulation of fatty acid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of low-density lipoprotein receptor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of miRNA transcriptionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of SMAD protein signal transductionManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of vascular associated smooth muscle cell apoptotic processManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of blood pressureManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of cellular response to insulin stimulus1 PublicationIC:ComplexPortal
Regulation of cholesterol transporter activity1 PublicationIC:BHF-UCL
Regulation of circadian rhythmISS:UniProtKB
Regulation of lipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIISS:UniProtKB
Response to lipidBy SimilarityISS:BHF-UCL
Response to nutrientManual Assertion Based On ExperimentTAS:ProtInc
Retinoic acid receptor signaling pathwayManual Assertion Based On ExperimentIDA:GO_Central
Rhythmic processIEA:UniProtKB-KW
Signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL
White fat cell differentiationISS:HGNC-UCL

Nucleus
Cytoplasm
Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.

Obesity (OBESITY):
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Lipodystrophy, familial partial, 3 (FPLD3):
A form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.
Glioma 1 (GLM1):
Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.

O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes.
Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity).