PPFIBP1

PPFIBP1 is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. PPFIBP1 was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Full Name

PPFIA binding protein 1

Function

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.

Biological Process

Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Neuromuscular junction developmentManual Assertion Based On ExperimentIBA:GO_Central
Synapse organizationManual Assertion Based On ExperimentIBA:GO_Central