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PPP2R5D

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

Full Name

protein phosphatase 2, regulatory subunit B', delta isoform

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Biological Process

Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of protein dephosphorylationIEA:Ensembl
Protein dephosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionIEA:InterPro

Cellular Location

Cytoplasm
Nucleus
Nuclear in interphase, nuclear during mitosis.

Involvement in disease

Intellectual developmental disorder, autosomal dominant 35 (MRD35):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.

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Anti-PPP2R5D antibodies

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Mouse Anti-PPP2R5D Recombinant Antibody (5E7) (CBMAB-P2649-YC)

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Target: PPP2R5D

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5E7

Application*: P

Mouse Anti-PPP2R5D Recombinant Antibody (4E12) (CBMAB-P2648-YC)

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Target: PPP2R5D

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4E12

Application*: E, WB

Mouse Anti-PPP2R5D Recombinant Antibody (1A3) (CBMAB-P2647-YC)

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Target: PPP2R5D

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1A3

Application*: E, IF, WB

Mouse Anti-PPP2R5D Recombinant Antibody (10D11) (CBMAB-P2646-YC)

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Target: PPP2R5D

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10D11

Application*: WB

Mouse Anti-PPP2R5D Recombinant Antibody (H5D12) (CBMAB-1695-CN)

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Target: PPP2R5D

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: H5D12

Application*: IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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