RXRG
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Full Name
Retinoid X Receptor Gamma
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Biological Process
Biological Process anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heart developmentIEA:Ensembl
Biological Process neuron differentiationIEA:Ensembl
Biological Process peripheral nervous system developmentIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of myelinationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to retinoic acidManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retinoic acid receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process skeletal muscle tissue developmentIEA:Ensembl
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heart developmentIEA:Ensembl
Biological Process neuron differentiationIEA:Ensembl
Biological Process peripheral nervous system developmentIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of myelinationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to retinoic acidManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retinoic acid receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process skeletal muscle tissue developmentIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
Cytoplasm
PTM
Acetylated by EP300.
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Anti-RXRG antibodies
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Target: RXRG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Human
Clone: 12RX-2D3
Application*: E, IF, WB
Target: RXRG
Host: Mouse
Specificity: Human
Clone: CBWJN-1669
Application*: WB, IC, P, IH-F, E
Target: RXRG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: H3210
Application*: WB, IP, E
Target: RXRG
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: G-6
Application*: WB, IP, IF, E
Target: RXRG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNR-906
Application*: WB
Target: RXRG
Host: Mouse
Specificity: Human
Clone: A-2
Application*: WB, IP, IF, E
Target: RXRG
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 9i204
Application*: WB
Target: RXRG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6H1
Application*: E, WB
Target: RXRG
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D3
Application*: E, WB, ICC
Target: RXRG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 1373
Application*: WB
Target: RXRG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H4
Application*: IP, M
Target: RXRG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5G6
Application*: IP, M
Target: RXRG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5C9
Application*: IP, M
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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