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RXRG

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Full Name

Retinoid X Receptor Gamma

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

Biological Process

Biological Process anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heart developmentIEA:Ensembl
Biological Process neuron differentiationIEA:Ensembl
Biological Process peripheral nervous system developmentIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of myelinationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to retinoic acidManual Assertion Based On ExperimentIBA:GO_Central
Biological Process retinoic acid receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process skeletal muscle tissue developmentIEA:Ensembl

Cellular Location

Nucleus
Cytoplasm

PTM

Acetylated by EP300.

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Anti-RXRG antibodies

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Recombinant Mouse Anti-RXRg Recombinant Antibody (12RX-2D3) (CBMAB-XB1013-YC)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse, Human

Clone: 12RX-2D3

Application*: E, IF, WB

Mouse Anti-RXRG Recombinant Antibody (CBWJN-1669) (CBMAB-N4241-WJ)

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Target: RXRG

Host: Mouse

Specificity: Human

Clone: CBWJN-1669

Application*: WB, IC, P, IH-F, E

Mouse Anti-RXRG Recombinant Antibody (H3210) (CBMAB-R3977-CN)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: H3210

Application*: WB, IP, E

Mouse Anti-RXRG Recombinant Antibody (G-6) (CBMAB-R3976-CN)

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Target: RXRG

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: G-6

Application*: WB, IP, IF, E

Mouse Anti-RXRG Recombinant Antibody (CBCNR-906) (CBMAB-R3975-CN)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNR-906

Application*: WB

Mouse Anti-RXRG Recombinant Antibody (A-2) (CBMAB-R3974-CN)

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Target: RXRG

Host: Mouse

Specificity: Human

Clone: A-2

Application*: WB, IP, IF, E

Mouse Anti-RXRG Recombinant Antibody (9i204) (CBMAB-R3973-CN)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 9i204

Application*: WB

Mouse Anti-RXRG Recombinant Antibody (6H1) (CBMAB-R3972-CN)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 6H1

Application*: E, WB

Mouse Anti-RXRG Recombinant Antibody (2D3) (CBMAB-R3971-CN)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D3

Application*: E, WB, ICC

Mouse Anti-RXRG Recombinant Antibody (1373) (CBMAB-R3968-CN)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: 1373

Application*: WB

Mouse Anti-RXRG Monoclonal Antibody (5H4) (CBMAB-0069-LY)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5H4

Application*: IP, M

Mouse Anti-RXRG Monoclonal Antibody (5G6) (CBMAB-0068-LY)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5G6

Application*: IP, M

Mouse Anti-RXRG Monoclonal Antibody (5C9) (CBMAB-0067-LY)

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Target: RXRG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5C9

Application*: IP, M

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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